As has been discussed in many questions around here (e.g. here), relativity tells us only about local properties and behavior of a space-time. There are some exceptions when we make global assumptions - if we have a space of globally and strictly constant positive curvature, non-trivial topology is imminent because the space has to be the 3-sphere $\mathbb{S^3}$.
But we can also add nontrivial topology without much constraints. The full richness can be explored e.g. through quotienting the "canonical" space-slices $\mathbb{E^3},\mathbb{S^3},\mathbb{H}^3$ (flat euclidean, 3-sphere, 3-hyperbolic) by a discrete symmetry group $\Gamma$. I.e. for $\Gamma$ a group of discrete translations in all directions "cutting up" $\mathbb{E}^3$, we get a topological 3-torus $\mathbb{E^3}/\Gamma = \mathbb{T^3}$.
The intuitive picture is that the space looks locally exactly as our good olde' flat euclidean space $\mathbb{E^3}$, but after a certain distance (the translation), we get to the same place. Naturally, as this is the same place, we should find the same things at these places up to their movement and evolution during the time we weren't there.
As for cosmological observation, if we are to detect nontrivial topology with current methods, the space or the non-trivialities must be "sufficiently small". Imagine we are on a sphere and we are restricted by observation to see a very very small patch of it - there will be no way we can conclude it is a sphere.
If we however see beyond say one of the discrete translations of $\Gamma$, we should be in principle able to detect multiple images of the same object. The problem is, since light took longer to travel from the image farther away, we will see the more distant object to be "younger" than the closer one and most probably under a different angle. For a decently large universe with other effects like redshift and obscuring, this is probably a deal-breaker.
Nevertheless, the endurance of scientists is endless. We may detect a repetition in the images when collecting large amounts of data for all visible objects and using certain correlation methods to evaluate them. Certain types of topological non-triviality would then be visible as peaks or "spikes" in the correlation indicators.
The deepest image of the universe is the CMB, of which we have a very detailed dataset. CMB can be viewed as a snapshot of a large sphere at luminous distance $\chi_{CMB}$. If this sphere intersects a topological non-triviality, we should see "circles" or certain pattern repetitions in the CMB. So long, the few tests of the data however did not reveal any of this. If anything, an $\mathbb{R^2}\times \mathbb{S^1}$ (a "3-tube") topology is conjectured in association with the slightly preferred direction of the CMB.
There are possible indirect tests suggested by the discussion of ACuriousMind - a non-trivial topology imposes different boundary conditions on fundamental fields and other possible objects. Note however that the theory we develop means "very far" by $\infty$. That is e.g. in particle experiments, "very far" may be a distance of few meters, not cosmological scales. Effects due to topologically different boundary conditions would most probably play an important role in the very early universe and might provide indirect tests of the cosmic topology.
My main source for this answer are this and this review article.