Kinematically, yes. In terms of describing the positions of objects, it is equivalent to say "A is accelerating away from B" and "B is accelerating away from A". However, it is an observed fact that the universe treats these two situations differently. A and B can check whether they feel artificial gravity in their reference frame. If so, it's accelerating. As far as I know, the "way the universe decides" to break this symmetry is a topic of continuing speculation.
Check out some related questions:
Inertia in an empty universe
Is acceleration an absolute quantity?
Is rotational motion relative to space?
Acceleration in special relativity
Newton's Bucket
What if the universe is rotating as a whole?