The torus is special because it's so simple, and because it provides the most tractable example of Mirror Symmetry https://en.wikipedia.org/wiki/Mirror_symmetry_(string_theory), a generalization of T-duality (which relates Type IIB with Type IIA with one another).
Toric compactifications are rather special, they're a special case of an incredibly large number of possible compactifications. The condition for the preservation of SUSY in the compactified theory was worked out in http://www.sciencedirect.com/science/article/pii/0550321385906029, and found to be that the 6-dimensional compactified space be a so-called Calabi-Yau manifold. Other compactifications are of course possible, but they do not preserve SUSY.
Both the torus and the Calabi-Yau's are Ricci flat, i.e. $R_{ab} = 0$. The $S^5$ has positive curvature, and when the compactified manifold has curvature, this curvature sources the other fields and makes a simple solution hard to find. Simple examples of compactifications on positively curved spaces include the famous $AdS_5 \times S^5$ compactification of Type IIB string theory. Here, the positive curvature of the sphere is balanced by the negative curvature of the AdS space, and moreover, the curvature lengths of the two are equal, so the sphere is in no sense "small", and this is therefore not a proper compactification in the usual sense.
It is not true that two manifolds which are topologically related will preserve the same symmetries, and also note that $S^5$ is not topological to $T^5$ as you say. This can be seen by comparing the Betti numbers, for example.