It's a truism that in science it is at least as important to state the reasons why a theory or idea might be wrong, as to state the reasons why it is might be correct. For example, early renormalization methods made experimental predictions that were very accurate, but the inventor's famously worried for decades about the conceptual problems of divergences; and many of their papers/articles/books on the subject include a long discussion about how acutely worried they were that their method for handling divergences was deeply flawed somehow.
My intention with this post is not to engage any user in a debate about whether string theory is true or not. I think anyone who takes string theory seriously should be happy to acknowledge as clearly as possible all the potential theoretical issues/problems with the theory.
Therefore I would like to ask, what are the major theoretical problems which would lead a reasonable person to be worried that string theory is not an accurate theory? I am excluding the fact that string theory has made no (major) predictions that have been confirmed, I am only interested in conceptual and theoretical ideas which might discredit the theory.
Please keep all answers to one issue per post.