There is nothing in physics that describes the sort of folding shown in your picture. I'm afraid it is an invention of the Science-Fiction community.
The best tool we currently have for describing spacetime is general relativity, but GR does not and cannot tell us anything about the global topological properties of spacetime. The sort of wormhole you show is described by the Morris-Thorne metric. Leaving aside the inconvenient detail that the Morris-Thorne wormhole requires exotic matter, which (probably) doesn't exist, all GR tells us is that the wormhole links two flat regions of spacetime. So it looks like:

where $A$ and $B$ are two regions of flat spacetime. However the two regions $A$ and $B$ would (in this 2D representation) remain as two flat parallel sheets everywhere with no other joins between them. In effect they would be two different universes joined by the wormhole not different regions of our universe.
There are some other related questions that you might be interested in reading: