In undergraduate courses the introduction to Hamiltonian mechanics usually starts from a Newtonian view point. One has equations of motions of the form (not sure if it is ok to use covariant notation for forces, but I will do it anyway):
$F_\mu = -\frac{\partial V}{\partial x^\mu}$
Then assuming certain properties of the potential (e.g. that it is independent of the velocity coordinates) one can show that it can be represented by Hamiltonian mechanics.
Now my question is if the systems that do not fulfill these conditions (e.g. dissipative systems, two energy conserving examples are given @JohnSidles answer to this question). Can such systems be quantized in any meaningful sense?
What I am really trying to achieve with this question is to understand better what quantization actually is. We usually have a Hamiltonian system and replace the Poisson bracket by commutation or anti-commutation relations and promote the functions to operators. But is this necessary for quantization or is there an underlying principle that can also be applied to other things?