Typically, one thinks of Hubble's constant in terms of astronomical observation. This begins with Hubble's empirical law:
$$v = H d$$
Where $v$ is the velocity derived from the redshift of a distant galaxy, and $d$ is the distance to it. The classic observational units for $H$ are therefore $\frac{\rm m/s}{\rm Mpc}$. Relativists hate carrying around more than one unit, though, so we convert the Megaparsecs to meters, and end up with inverse seconds (or meters, since $c$ gives us a way to convert back and forth).
More simply, we can also think of Hubble's constant in terms of the Robertson-Walker metric:
$$ds^{2} = -dt^{2} + a^{2}(t)d^{3}{\vec x}$$
Where $d^{3}{\vec x}$ is the 3-metric of a homogenous space. Then, $a(t)$ tells us how "big" space is at the current time, and we can think of the rate of expansion as $H(t) = \frac{\dot a}{a}$${}^{1}$, which obviously has units of inverse time.
Note that $H$ is actually a function of $t$ and is not constant in time, except for some special cases.
EDIT:
Note, if what you care about is the time evolution of 3-volumes, you can see that these are proportional to $a^{3}V_{0}$. A time derivative of this then gives you $\frac{dV}{dt} = 3{\dot a}a^{2}V_{0} = 3 H a^{3}V_{0}$, which has the units you want, but is still logically anterior to the ordinary Hubble constant.
${}^{1}$We divide by $a$ so that $H$ doesn't depend on our arbitrary choice of the scale of $a$, and simply reflects the relative rate of expansion.