A $W^{+/-}$ particle can change a quark from one generation into a quark of a different generation, as long as these quarks (obviously) differ 1 or -1 in electric charge. So an up quark ($+\frac 2 3$) can be changed in a strange quark ($-\frac 1 3$) by means of a $W^-$ vector boson.
But why can't (for example) a $Z^0$ change a muon in an electron neutrino. I think conservation of lepton number offers no answer because is a rule which follows from experiment. Conservation of baryon number is also a conservation rule, but nevertheless, the decay of the proton is believed to be possible. So maybe it will also be possible to change a muon in an electron neutrino (or a muon in an electron).