Remember that for a 1/2 spin particle the only states we have are spin up $|\uparrow >$ and spin down $|\downarrow >$, or a general linear combination of both:
$$
\chi = \cos{(\beta/2)} e^{-i\alpha/2} \binom{1}{0}+\sin{(\beta/2)} e^{i\alpha/2} \binom{0}{1} = c_1 |\uparrow > + c_2 |\downarrow >
$$
Through the angles $\beta$ and $\alpha$ we express exactly the value of the coefficients $c_1$ and $c_2$, i.e., we specify the linear combination. It's more clear if we imagine the state $\chi$ located on the surface of a unit radius sphere (the so called Bloch sphere). The polar angle $\beta$ and the azimutal angle $\alpha$ specify the location on the sphere. For example, $\alpha=\beta=0$ (the north pole of the sphere) would be state $\chi =|\uparrow > $. In the same way, the south pole would represent $|\downarrow > $.
The angle $\beta$ gives information about the $\textbf{population}$ of the quantum state: when we have many spin 1/2 particles, it will tell us in which proportion the particles are on state up and which proportion are in state down. For a single particle, it will just tell if it's more likely that this particle is in state up or state down. The phaseangle $\alpha$ gives information about the $\textbf{coherence}$ of the quantum state: it's only relevant when we have a superposition of both states: it will tell how strong is the superposition. If this angle is zero, there's no superposition at all (decoherence, state can only be in state up or down).
Therefore they're relevant angles. But when measuring, a common phase factor will not affect at all, because the probabilities remain the same (that's what they mean with physical significance). A new state $\chi'$:
$$
\chi'= e^{i\alpha/2} \chi = \cos{(\beta/2)} \binom{1}{0}+\sin{(\beta/2)} e^{i\alpha} \binom{0}{1}
$$
will follow the normalization condition:
$$
|<\chi' | \chi'>|^2 = \cos^2{(\beta/2)} + \sin^2{(\beta/2)} = 1 = |<\chi | \chi>|^2
$$
(since $|\uparrow >$ and $|\downarrow >$ form an orthonormal basis), and will lead to the same probabilities as $\chi$. For example, the probability of measuring state $|\uparrow >$ in state $\chi$ is the same as measuring in state $\chi'$:
$$
|<\uparrow| \chi'>|^2 = \cos^2{(\beta/2)} = |<\uparrow | \chi>|^2
$$