In a way, yes, in general relativity.
As mentioned in other answer, infinitesimal square of the distance in flat 4D spacetime (aka Minkowski space), appearing in special relativity, is given by
\begin{equation}
ds^2=-c^2 dt^2 + dx^2 + dy^2 + dz^2.
\end{equation}
Things become a bit more complicated in general relativity, because the spacetime can be curved. In general, it becomes
\begin{equation}
ds^2=g_{\mu\nu}dx^\mu dx^\nu,
\end{equation}
where $g_{\mu\nu}$ is something called a metric tensor and we use Einstein summation convention in which summation over repeated indices is implied, i.e. RHS is summed over $\mu$ and $\nu$ ranging from 0 to 3 in 4D spacetime. In spherical coordinates, this looks like
\begin{equation}
ds^2=-c^2 dt^2 + dr^2 + r^2(d\theta^2+\sin^2 \theta d\phi^2).
\end{equation}
In special relativity in Cartesian coordinates, $g_{\mu\nu}$ is just a diagonal matrix with $g_{00}=-1$, $g_{11}=1$, $g_{22}=1$, $g_{33}=1$ and other entries zero, but in general relativity there are many options.
In classical general relativity, only fundamental difference between space and time is the difference in sign of eigenvalues of the metric tensor.
Now, if we have a spacetime with a point mass, then we have Schwarzschild metric, given by:
\begin{equation}
ds^2=-\left(1-\frac{2GM}{c^2r}\right)c^2 dt^2 + \left(1-\frac{2GM}{c^2r}\right)^{-1}dr^2 + r^2(d\theta^2+\sin^2 \theta d\phi^2),
\end{equation}
where $M$ is mass.
The distance $r_s=2GM/c^2$ is called Schwarzschild radius. If mass is contained inside its Schwarzschild radius, it is a black hole with event horizon (point of no return) at distance $r_s$.
Now, notice that, in metric, coefficients multiplying $dt^2$ and $dr^2$ switch signs when $r$ becomes smaller than $r_s$. This means that, in a way, radial and temporal coordinates have switched their roles as space and time coordinates!
This also means that $r$ will inevitably grow smaller for unfortunate space traveler who crossed the event horizon, just like e.g. $t$ inevitably grows bigger for anybody in flat spacetime. The center of black hole stops being something "over there" once you crossed the horizon, it literally becomes your future.