Maybe there is more context that qualifies this statement, but taken as is, it's completely false. In general, when we talk about existence of solutions to a differential equation, we're talking about existence given a certain set of boundary conditions. It's perfectly possible, in practical real-world problems, that we can have constraints on the boundary conditions, and if our boundary conditions don't satisfy those constraints, there is no solution.
For example, I could write down a differential equation representing the free motion of a body in a viscous medium. I could then specify the following boundary conditoins: at $t=0$ its velocity is zero, and at $t=t_f>0$ its velocity is nonzero. There is no such solution.
In physical problems where we specify the initial conditions, we want not just existence but uniqueness of solutions.
Less trivially, we can have examples of inconsistency or indeterminism (solution exists, but is not unique) in physical problems that come up in interesting, "meaninful" contexts. Examples include Norton's dome, naked singularities, and the Novikov consistency principle.