We know that space-time dimensions are 3+1 macroscopically, but what if 2+2? Obviously it is tough to imagine two time dimensions, but mathematically we can always imagine as either having two parameters $t_1$ and $t_2$ or else in Lorentz matrix $$\eta_{00} = \eta_{11} = -1$$ and, $$\eta_{22} = \eta_{33} = 1.$$
Is there any physical reason for not taking this, like the norms become negative or something else?