To give some context for what I have in mind, here's the best answer I came up with myself. Corrections, comments and better answers would be much appreciated.
The proper mathematical context to discuss this question are the renormalization group equations. For example, in $\phi^4$-theory we have:
$$ \lambda_R(s_1) = \lambda_R(s_0) +C \ln \left( \frac{s_1 }{s_0}\right) \lambda_R^2(s_0) + \ldots $$
The idea is that we choose some reference scale $s_0$. By definition, the process is at this scale completely described by the simple single-vertex diagram with coupling $\lambda_R(s_0)$ at the vertex. But as soon as we probe the process at a different scale $s_1$, we must take corrections into account which are described by the renormalization group equation. Formulated differently, if we consider a perturbative expansion in the renormalized coupling at reference scale $s_0$, $\lambda_R(s_0)$, we only describe the process completely by the simple single vertex diagram at scale $s_0$. At any other scale $s_1$, we must take corrections due to additional diagrams into account. In this sense, the effects of virtual particles (which correspond to lines in the loop) become important at higher energy scales.

In particular, higher order correction become more and more important as we move farther away from $s_0$. This is a result of the logarithmic dependence on $s_1/s_0$. In this sense, the effects of virtual particles become even more important at higher energy scales. And, as a result, the charge becomes, at least in this case, more anti-screened.