In the following I'm going to talk about the relation between information and science
When the information that is available to you is purely local information your assessment of your situation is inherently limited to that local information.
Let's say you find yourself in a small room, and as far as you can tell there is zero G. Your own physical sense is that there is zero G, accelerometers attached to the wall of the room read zero G.
You could be in a spacecraft in interstellar space, or you could be in a spacecraft in orbit around a planet in a solar system. Maybe very, very sensitive can be developed that can tell the difference, but for the purpose of this thought experiment: local measurement cannot tell the difference.
Next you widen your perspective, and the information available to you now is that the spacecraft is orbiting an earth sized celestial body. Newtonian theory and Einsteinian theory have the following in common: size matters. Given that the mass of the celestial body is many many times the mass of the spacecraft we say unequivocally: the spacecraft is orbiting the celestial body.
Next question:
Can we determine with purely local measurement whether the celestial body is orbiting a star or in interstallar space? That is, in this thought experiment you are only allowed to look inward; no observation of anything that happens away from the surface of the celestial body. The confinement to local measurement is very restrictive.
Rotation of the celestial body: no problem, our technology has rotation sensors that can measure very slow rotation rates. But if the information available to you is local measurement only I think you'd be hard pressed to tell whether the celestial body is orbiting a star.
You widen the perspective again: the solar system as a whole. Now again there is that common ground of newtonian and einsteinian theory: the planets are orbiting the common center of mass of the solar system as a whole.
Widen your perspective again: the stars of the Galaxy are orbiting the center of mass of the Galaxy.
Each of these levels of perspective take a group of gravitationally bound objects. Such a grouping is natural level of perspective.
Going back to the example of jumping of and starting to fall:
If you confine yourself to local information only then you cannot tell the difference. prior to jumping: an accelerometer on your person reads that you are experiencing an acceleration of 1 G, upwards. During the fall the accelerometer on your person reads that you are experiencing zero G.
What Brian Greene is referring to is this inability to tell the difference if you are confined to local measurement only.
From a scientific point of view: confining yourself to limited information is the last thing you want to do.
The whole point of doing science is that you bring all available information to bear.
Let me make a comparison:
In the history of physics there was a time that the caloric theory of heat was a prominent theory. For example, when Sadi Carnot developed the work that is the foundation of thermodynamics he was thinking in terms of caloric theory. That is, in its day caloric theory was scienfifically fruitful, it has been conducive to science that has stood the test of time. Over time caloric theory was replaced with the molecular theory of heat.
Thought experiment: if you deprive yourself of the information that caloric theory is obsolete (and why it is obsolete) then caloric theory is valid and relevant.
Obviously that's a pointless exercise. Depriving yourself of relevant information is the opposite of what science is about.