Every major theory in physics - from classical dynamics, to quantum mechanics, to general relativity - makes assumptions about the structure of spacetime. Among the most common assumptions are that spacetime is:
- uncountable (in the sense that the set of points that we identify as "spacetime" has cardinality greater than that of the natural numbers)
- everywhere dense (in the sense that for any two points $a\ne b$ there is a third point $c$ such that the distance from $a$ to $c$ is less than the distance from $a$ to $b$)
- smooth (in the sense that every geodesic is a differentiable curve)
- [almost] everywhere continuous (in the sense that spacetime is simply connected outside of singularities)
The application of analysis, probability, and topology to physics relies on these assumptions; in almost every case, spacetime is treated as a subspace of real or complex $n$-space (usually $\Bbb{R}^4$).
Now I could ask "but what if spacetime doesn't work that way?" - but that dead horse has already been beaten enough. Instead, I have a much more practical question:
Why should spacetime have the structure of a smooth, connected, topological, vector, etc. space?
That is, what observations or experiments, if any, suggest the continuity/uncountability/density/and-so-on of spacetime?
I've found this question particularly difficult to answer - chiefly because I've been unable to reconcile the infinite precision of mathematical statements with the practical limitations of physical measurement. For every case I can think of, the conclusion can be invalidated by the existence of a nonzero margin of error.
For example, we could say that a countable spacetime ought to have a nonzero probability of some event $\gamma$ occurring within a particular countable set $S$. We could perform measurements to show that the frequency of $\gamma$ within $S$ matches that predicted by the calculated probability - but there's some tolerance in our measurement that raises the possibility that the event only ever occurs sufficiently close to, but never at, a point in our set.
This all happens without regards to the details of the setup - which may very well require an infinite number of points and/or measurements, or any number of other impossibilities. Even so, the fact that any measurement will only indicate that an event has occurred within some minimal distance of a point in $S$ means that an uncountable spacetime could yield the same result. That is, if the probability of observing $\gamma$ in $S$ is $0$ - courtesy of the measure on $S$ being $0$ - we might still observe $\gamma$ sufficiently close to $S$, because the probability of $\gamma$ occuring within a nonzero distance of $S$ is nonzero.
Similar arguments can be constructed for the other assumed properties of spacetime. In all cases, it seems that the same results can be obtained in one hypothetical spacetime as can be in another as long as there is some tolerance for error in the measurement.
Edit:
In response to comments, and the recent edit of this question, I would like to address two things.
Firstly, I get the impression that this question is being interpreted as "why isn't spacetime discrete?" This seems to be based on an assumed dichotomy between "continuous" and "discrete" spacetime. This dichotomy is, however, almost entirely artificial. I listed the above four criteria individually because they are, for the most part, independent of one another. There are hypothetical spacetimes which are neither continuous (in the sense usually intended), nor discrete. For example, spacetime could be continuous without being smooth, uncountable without being dense, or dense without being continuous. Without some kind of experimental verification, the choice between any of these amounts to a matter of... well, choice.
Secondly, I am not asking for an explanation of the "true nature" of spacetime - as it stands, such a question would be meaningless. The issue I am trying to address is that vastly different spacetimes "look" the same below a certain (possibly infinite) "resolution". For instance, a spacetime which is uniformly "rough" at the sub-subatomic scale is indistinguishable from a uniformly smooth spacetime at the cosmic scale. This is the problem I am facing: how do we verify that our spacetime is the smooth one rather than the rough one (or uncountable rather than countable, etc.).