As far as experiments have been able to tell, spacetime is topologically trivial. Fiber bundles over topologically trivial spacetime are necessarily trivial, so sections are just functions. But if we had some reason to consider spacetimes with nontrivial topology, then nontrivial fiber bundles (where we need sections instead of just functions) would become relevant. I'll mention two good reasons for considering spacetimes of nontrivial topology: one relatively straightforward, and one speculative. Both are active research topics today.
A straightforward reason
QFT is hard. Perturbative methods (small-coupling expansions, represented by Feynman diagrams) can only get us so far in our understanding of QFT. Different-looking QFTs can turn out to be physically equivalent, and a theory's predictions at low energy can look very different than the structure that was used to define it at high energy. The classic example is quantum chromodynamics (QCD), which is defined in terms of quark and gluon fields, but at lower energies, QCD correctly predicts that we should only see mesons and baryons. Understanding 't Hooft anomalies can help us diagnose which different-looking QFTs are equivalent to each other, and which QFTs can arise as low-energy effective models of other QFTs.
An 't Hooft anomaly is an obstruction to promoting a theory's rigid symmetry to a gauge symmetry. (For a taste of what the study of 't Hooft anomalies involves, see Witten (2015), Anomalies Revisited, https://member.ipmu.jp/yuji.tachikawa/stringsmirrors/2015/6-2.00-2.30-Edward-Witten.pdf). Understanding a theory's 't Hooft anomalies is more informative than merely understanding its symmetries. This extra information often reaches farther than perturbation theory can see, and it becomes even more enlightening when we consider QFTs formulated on a whole family of spacetime topologies instead of on just one. That's a reason for considering topologically nontrivial spacetimes, which in turn requires considering nontrivial fiber bundles, where most sections are not mere functions.
A speculative reason
Spacetime is almost certainly an emergent phenomenon. Even though it's a fundamental ingredient in the two established pillars of modern physics, quantum field theory and general relativity, string theory (the most promising path toward reconciling those two pillars with each other) suggests that spacetime as we know it is only an approximation. Any QFT that arises as a low-energy approximation to string theory might need to be definable in spacetimes of nontrivial topology, even if such topologies aren't directly relevant at lower energies where quantum gravity effects are negligible. That means they can't have any 't Hooft anomalies in the symmetries that need to be gauged, in spacetimes of any topology — at least any topology that is consistent with any other important restrictions, like admitting a spin structure.
The Standard Model of Particle Physics satisfies that condition: its gauged symmetry group doesn't have any (known) 't Hooft anomalies on the relevant family of spacetimes. This is stated below equation 3.5 on page 24 in arXiv:1808.00009, which says that the standard model defines a consistent quantum theory in any background, of any topology. That's probably not just a random coincidence.