Coulomb's Law is $$F=k\frac{q_1 q_2}{r^2}$$ where $F$ is the force, $k$ is the Coulomb's universal constant, $q_1$ and $q_2$ are the charges, and $r$ is the distance between the two charges.
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Theres nothing "positive" or "negative" about charges other than the fact that they add destructively to the field/potential. you could have called them red and blue if you wanted. – Señor O Jan 21 '22 at 03:01
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3https://xkcd.com/567/ – Sandejo Jan 21 '22 at 03:43
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Related: https://physics.stackexchange.com/q/17109/2451 and links therein. – Qmechanic Jan 21 '22 at 15:54
6 Answers
If protons were negatively charged, and electrons were positively charged, this would be equivalent to flipping the signs of all charges$^*$. Given that, it is quite simple to check that Coulomb's Law obeys charge symmetry, by applying the substitutions $q_1\to-q_1$ and $q_2\to-q_2$. $$F = \frac{kq_1q_2}{r^2} \to \frac{k(-q_1)(-q_2)}{r^2} = (-1)^2\frac{kq_1q_2}{r^2} = F$$ Therefore, there would be no difference if we switched the sign convention of the charges.
$^*$I should note that, technically, switching the charges of protons and electrons would not be entirely equivalent to flipping the signs of all charges, since one could imagine doing this without changing the signs of the charges of other particles, like muons and pions. However, doing this would mean that, for instance, the process $\mu^-\to e^-\nu_\mu\bar\nu_e$ would become $\mu^-\to e^+\nu_\mu\bar\nu_e$, which clearly violates charge conservation.

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No because the law is dependent on the charges, not masses. Switching around which particle gets which charge will keep the sign on the equation the same. Opposites still attract and likes repel.

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All of the other answers assume the mathematical theory is correct. Physics is, however, an experimental science, and looking for discrepancies between the math and reality is a constant theme.
Experimenters have created and characterized antihydrogen, with negative antiprotons and positive antielectrons. Its measured properties confirm that Coulomb's law works as expected in this case.

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Choosing positive charge for proton and negative for electron is a matter of convention, so flipping them would change nothing...
...unless we take into account other charged particles. If only the charges of proton and electron are changed, but not of the other charged particles, this may produce some unpredictable consequences... or it may not. Or it may not be possible at all from the point of view of the fundamental symmetries of the Unievrse (of which partciles are an expression).

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Call the electrons as protons and vice versa. That's the effect your question has.

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7This answer is misleading, since there are more differences between electrons and protons than just charge. – Sandejo Jan 21 '22 at 06:28
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There are differences. But the formula considers q1 and q2 as two points with charges. It does not care about other properties. – Tojra Jan 21 '22 at 09:03