This is more a long comment than an answer, you can skip until the end if you want.
I am not a downvoter but I had a notification and regarding your comments, it appears to me that you are confusing two things:
Space-time is a mathematical framework, and we build our theories on it.
The consequences of general relativity, a theory of space-time, are observable and in a sense 'real'.
But the successes of our theories built on space-time (whether it is curved or not), say nothing about the realness of this mathematical concept. There is for example the block universe interpretation, which is a philosophical viewpoint of space-time saying that every instant of the universe exists, and the appearance of the flowing of time is but an illusion. What I mean here is that if there are different interpretations of space-time in general relativity, then the concept is unclear in common sense, even though mathematically speaking, it is perfectly defined.
Another possible interpretation is that space-time is an a posteriori concept. I mean by this the following:
- Each instant passes in 'reality' (with your definition of it) and when we pile them up, we can describe what happened with theories in the framework of space-time.
This is very different from saying 'space-time is real', and it fits nicely with the way physical theories are thought of: just mathematical entities that describe what is happening in experiments. Indeed an a posteriori vision of these theories built on space-time may give the illusion we can predict events time after time. But in fact, we just constructed for future (or hypothetical) events a four-volume that can be thought of as the mathematical version of a 'mini-block universe', and it happens that the events inside it match the flowing of time in our observations.
All this to say:
Frame dragging, time dilation, and all predictions of theories based on space-time that were observed do not mean space-time is real, just that we have a theory that fits the data. That is to say, the Universe works the way it does, we describe it through mathematics, but it doesn't mean the mathematical concepts involved are 'real' or have a physical counterpart.
I will go a little further and say that these very questions you are asking are the sign of this very unrealness of space-time.