Suppose you have non-relativistic fermions scattering off a delta function potential.
It is an easy job to solve $H=-\partial_x^2+\epsilon \delta(x)$ by starting with an eigenfunction of the form $\psi(x)=(A e^{-ikx}+B e^{ikx})\theta(-x)+(C e^{-ikx}+D e^{ikx})\theta(x)$ and looking at the continuity of the function at $x=0$ and discontinuity of the slope of the wavefunction at $x=0$. Then one can compute the S-matrix.
It is also easy to solve Hamiltonian describing two fermions with attraction/repulsion at the point of contact i.e. $H=-\partial_{x_1}^2-\partial_{x_2}^2+g\delta(x_1-x_2)$.
For example to solve above you start with the eigenstate of the form \begin{aligned} &\psi(x_1,x_2)=\theta\left(x_{2}-x_{1}\right)\left\{A \mathrm{e}^{\mathrm{i}\left(k_{1} x_{1}+k_{2} x_{2}\right)}+B \mathrm{e}^{\mathrm{i}\left(k_{2} x_{1}+k_{1} x_{2}\right)}\right\} \\ &+\theta\left(x_{1}-x_{2}\right)\left\{C \mathrm{e}^{\mathrm{i}\left(k_{1} x_{2}+k_{2} x_{1}\right)}+D\mathrm{e}^{\mathrm{i}\left(k_{2} x_{2}+k_{1} x_{1}\right)}\right\} \end{aligned}
and then demand the continuity of the eigenfunction at $x_1=x^2$ and the condition that the above function is eigenstate with eigenvalue $k_1^2+k_2^2$, we can compute the S-matrix relative the incoming and outgoing amplitudes.
Now, consider a problem mixing both of the cases. You have fermions scattering off the delta function potentials and also attracting/repelling each other at the point of contact i.e. take the Hamiltonian of the form \begin{equation} H=-\partial_{x_1}^2-\partial_{x_2}^2+\epsilon(\delta(x_1)+\delta(x_2))+ g \delta(x_1-x_2). \end{equation}
Now, how would one solve this problem?