According to this Wikipedia article on cosmic inflation:
The magnetic monopole problem, sometimes called the exotic-relics problem, says that if the early universe were very hot, a large number of very heavy, stable magnetic monopoles would have been produced.
Inflation solves this "problem" by diluting them as the universe expands (they are created before inflation and diluted during it).
But we have no evidence that such exotic particles even exist! They are predicted by grand unified theories which are in turn scantly supported by evidence.
Also, monopoles require a somewhat awkward modification to the magnetic potential.
So why is the "monopole problem" such a problem in the first place?