In the following lecture notes you can find a description of your question. The relevant parts here are: chapter 1.3.4, , 7.1 and 8.
We treat the particle in an electric field as a Hamiltonian system in the following way:Let $(Q,g)$ be a Riemannian Manifold and construct $T^{*}Q$ as the cotangent bundle with the canonical symplectic structure $\omega_0$. Now let us assume we have an electric field, that is a closed 2-form $F$ on $Q$. Pulling back $F$ along the canonical projection $\pi:T^{*}Q \to Q$, we obtain a symplecitc form on $T^{*}Q$ of the following form, where $e$ is the electric charge:
$$\omega=\omega_0+e\pi^{*} F.$$
It can be shown that $\omega$ is symplectic iff $F$ is closed. The proof can be found in the leccture notes. We now have obtained a Hamiltonian system $(T^{*}Q,\omega)$, which we want to quantize using the language of geometric quantization. In order to do this, we have to build a prequantum line bundle over this symplectic manifold, whose curvature is equal (up to some factors of i/h) to the symplectic form. In the lecture notes, you will find that for the system to be quantizable,a certain integrality condition needs to hold: the deRham cohomology class of the symplectic form needs to be in the image of the map $$i^2:H^2(T^{*}Q,\mathbb{Z}) \to H^2(T^{*}Q,\mathbb{C}).$$
Physically, this will correspond to the charge, $e$ being quantized, the condition for a quantization to exist will be a condition on $e$ from the symplectic form.
We can now turn to the question whether the quantization was unique or not. So what we did mathematically during the geometric quantization procedure is that we have built a $U(1)$ bundle over $T^{*}Q$ for some Riemannian manifold Q, whose curvature was equal to the symplectic form $\omega$. The non-uniqueness, as discussed in the lecture notes chapter 8 is in one-to-one correspondence with $H^1(T^{*}Q,U(1))$.
So, I think, what they really mean, is the integrality condition, namely that in order for the hamiltonian system to be quantizable, the symplectic form needs to be entire, i.e. its derham class satisfies the condition given above, or in the notes chapter 8.
As to not confuse notions, here we quantized a charged particle moving in an electric field.