I think that the point where technology reached the relativistic realm was when the first cyclotrons started to accelerate particles to relativistic velocities.
The very first cyclotron was a tabletop device. If memory serves me, within years of the first one a cyclotron was built with a chamber two meters in diamter. Each larger design accelerated to higher velocities.
The operating principle of a cyclotron is quite neat:
The centripetal force that is required to make the particle(s) move in circumnavigating motion is provided by the Lorentz force. Electromagnets are set up in such a way that there is a uniform magnetic field.
In the chamber the circumnavigating particles are spiraling outward; as the particles are being accelerated (twice every circumnavigation), they are going round in wider and wider circles. Upon every acceleration the velocity of the particles increases. However, the angular velcity of the particles remains the same because the particles are going round in wider and wider circles.
As we know: the larger the radius of circumnavigating motion, the larger the required centripetal force. The Lorentz force accommodates that perfectly; the Lorentz force is proportional to the velocity.
So: in the non-relativistic realm the proportionalities are linear, allowing a wonderfully simple cyclotron design.
The designers/builders of cyclotons knew in advance this linear behavior is limited to the non-relativistic realm.
Pushing for relativistic velocities the designers knew they had to take into account that a higher magnetic field density is required when the particles are accelerated up to relativistic velocities.
One approach is to create a specific non-uniform magnetic field. For instance, if you make the magnetic field stronger the farther away from the center then the machine can still have all particles go round at the same angular velocity.
In a ring accelerator, such as the Large Hadron Collider, the field strength of the deflecting magnets is increased over time, in order to keep providing the required deflection. In the case of the Large Hadron Collider: the particles that are injected are already close to the speed of light. Over a period of 20 minutes or so the kinetic energy of the particles is raised further. The strength of the deflecting magnetic fields is adjusted upward continously in order to keep providing the required deflection.
Summerizing:
particle accelerators were the first machines for which it was necessary to take relativistic effect into account. Not taking relativistic effect into account would result in poor performance.
Further reading: 2012 question titled Relativistic centripetal force