The questions you ask are really difficult to answer. Mass is not a property of space (or space-time itself), but of physical objects in classical physics. In General relativity, it is difficult to speak about mass clearly, there is no good general definitions.
Now, there are two naive metaphysics about space-time. The substantivalists think that space-time exists by itself, even if its not "made" out of something, and that if you remove all matter from it it is still here (but empty). The relationalists on the other hands, think that space-time is emerging from the relations between matter and that it does not make sense to speak of space-time itself without matter. For substantivalists, space-time has points that "really" do exists, while for relationalists it does not.
I said that these two approach where naive. Why ?
If you're a substantivalist, you would have to explain why space-time has points and why, if you do a Leibniz shift of all the matter inside it (that is, you shift all matter by a constant and add some constant velocity with respect to some inertial frame), then the resulting universe we measure is actually the same while its a different configuration.
Is there really a need to believe in points if two different configurations are indiscernible ? There is also the hole argument from Einstein in general relativity, but its much subtler (see http://en.wikipedia.org/wiki/Hole_argument).
Now, if you're a relationalist, you would have to explain why is acceleration absolute ? How comes that even if I'm alone in space-time, without referring to anything near or far away from me, I can know for sure if I'm accelerating (say, rotating) or not ?
This shows that space-time is not entirely relational, you can look at Newton's bucket for this deep argument.
What we can say, is that space-time is a weird thing we don't really understand. Yet, it is certain that it has an "inertial structure" that allows you to discriminate what it means to accelerate or to be "not moving" (that is, being inertial or following a geodesics in GR). How is that possible to reconcile the presence of an inertial structure without having points ? Nobody knows right now.
https://jila.colorado.edu/%7Eajsh/courses/astr5770_21/text.html
– William Martens Jan 06 '23 at 14:32